Research and analysis
NOIDs causative agents: week 50 (week ending 17 December 2023)
Updated 2 January 2024
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Laboratories in England have a statutory duty to notify the UK Health Security Agency (UKHSA) of the identification of the following causative agents:
- Bacillus anthracis
- Bacillus cereus
- Bordetella pertussis
- Borrelia spp
- Brucella spp
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter spp
- Carbapenemase-producing Gram-negative bacteria
- Chikungunya virus
- Chlamydophila psittaci
- Clostridium botulinum
- Clostridium perfringens
- Clostridium tetani
- Corynebacterium diphtheriae
- Corynebacterium ulcerans
- Coxiella burnetii
- Crimean-Congo haemorrhagic fever virus
- Cryptosporidium spp
- Dengue virus
- Ebola virus
- Entamoeba histolytica
- Escherichia coli O 157
- Francisella tularensis
- Giardia lamblia
- Guanarito virus
- Haemophilus influenzae (invasive)
- Hanta virus
- Hepatitis A
- Hepatitis B
- Hepatitis C
- Hepatitis D
- Hepatitis E
- Influenza virus
- Junin virus
- Kyasanur Forest disease virus
- Lassa virus
- Legionella spp
- Leptospira interrogans
- Listeria monocytogenes
- Machupo virus
- Marburg virus
- Measles virus
- Mpox (monkeypox) virus
- Mumps virus
- Mycobacterium tuberculosis complex
- Neisseria meningitidis
- Omsk haemorrhagic fever virus
- Plasmodium falciparum
- Plasmodium knowlesi
- Plasmodium malariae
- Plasmodium ovale
- Plasmodium vivax
- Polio virus
- Rabies virus
- Rickettsia spp
- Rift Valley fever virus
- Rubella virus
- Sabia virus
- Salmonella spp
- SARS coronavirus
- Shigella spp
- Streptococcus group A (invasive)
- Streptococcus pneumoniae (invasive)
- Varicella zoster virus
- Variola virus
- Vibrio cholerae
- West Nile virus
- Yellow fever virus
- Yersinia pestis
Statutory notifications of causative agents, grouped by root organism
Totals for the current week compared to the previous 5.
| Week notification received | 2023/45 | 2023/46 | 2023/47 | 2023/48 | 2023/49 | 2023/50 |
|---|---|---|---|---|---|---|
| Arboviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| West Nile virus | - | - | - | 1 | - | - |
| Bacillus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bacillus cereus | 12 | 16 | 19 | 17 | 11 | 13 |
| Bordetella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Bordetella pertussis | 13 | 14 | 12 | 14 | 15 | 24 |
| Borrelia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Borrelia burgdorferi | 17 | 15 | 37 | 30 | 20 | 26 |
| Borrelia sp | 7 | 4 | 6 | 4 | 6 | 6 |
| Brucella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Brucella sp | 2 | - | - | - | - | - |
| Burkholderia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Burkholderia pseudomallei | - | 1 | - | - | - | - |
| Campylobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Campylobacter coli | 30 | 39 | 40 | 34 | 21 | 27 |
| Campylobacter fetus | - | - | 1 | 1 | 1 | - |
| Campylobacter jejuni | 323 | 336 | 276 | 233 | 199 | 201 |
| Campylobacter lari | - | - | - | 1 | - | - |
| Campylobacter other named | - | 1 | - | 3 | - | - |
| Campylobacter sp | 991 | 1,066 | 997 | 970 | 825 | 833 |
| Campylobacter upsaliensis | - | 2 | 1 | - | 1 | - |
| Campylobacter ureolyticus (bacteroides corrodens) | 1 | - | - | 1 | - | - |
| Chikungunya virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Chikungunya virus | - | 1 | 1 | - | - | 1 |
| Clostridium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Clostridium perfringens | 21 | 38 | 39 | 29 | 26 | 34 |
| Clostridium tetani | - | - | - | 1 | - | - |
| Coronavirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Coronavirus | 18 | 14 | 23 | 18 | 39 | 44 |
| Human coronavirus 229e | - | 1 | - | 1 | - | 1 |
| Human coronavirus hku1 | - | - | 1 | 1 | 2 | 3 |
| SARS coronavirus | - | - | - | 1 | 1 | - |
| SARS-CoV-2 antibody indeterminate | 105 | 120 | 132 | 130 | 114 | 182 |
| SARS-CoV-2 antibody void | 2 | 2 | 7 | 4 | - | 2 |
| SARS-CoV-2 coronavirus (COVID-19) | 3,956 | 4,427 | 4,019 | 4,281 | 6,054 | 8,022 |
| SARS-CoV-2 coronavirus (COVID-19) indeterminate | 57 | 55 | 45 | 37 | 68 | 51 |
| SARS-CoV-2 IgG antibody negative | 41 | 36 | 34 | 38 | 30 | 67 |
| SARS-CoV-2 IgG antibody positive | 191 | 177 | 166 | 174 | 130 | 378 |
| SARS-CoV-2 total antibody negative | 33 | 67 | 24 | 30 | 14 | 35 |
| SARS-CoV-2 total antibody positive | 94 | 114 | 69 | 100 | 67 | 109 |
| Corynebacterium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Corynebacterium diphtheriae | 1 | 2 | 3 | 1 | 3 | 2 |
| Corynebacterium ulcerans | - | 1 | - | - | - | 3 |
| Cryptosporidium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Cryptosporidium cuniculus | 1 | - | 1 | - | - | - |
| Cryptosporidium hominis | 126 | 136 | 36 | 21 | 2 | 5 |
| Cryptosporidium meleagridis | - | - | 1 | - | - | - |
| Cryptosporidium parvum | 70 | 53 | 23 | 9 | 20 | 6 |
| Cryptosporidium sp | 57 | 97 | 141 | 137 | 105 | 124 |
| Cryptosporidium ubiquitum | 2 | - | 1 | - | - | - |
| Entamoeba | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Entamoeba histolytica | 1 | 1 | - | - | - | 4 |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli O 157 | 13 | 13 | 7 | 11 | 5 | 5 |
| Flaviviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Dengue virus | 2 | 4 | 8 | 9 | 10 | 4 |
| Haemophilus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Haemophilus influenzae | 73 | 80 | 61 | 68 | 69 | 68 |
| Hepatitis viruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Hepatitis A | 15 | 9 | 14 | 15 | 8 | 14 |
| Hepatitis B | 276 | 321 | 338 | 322 | 393 | 330 |
| Hepatitis C | 221 | 327 | 269 | 272 | 233 | 213 |
| Hepatitis D | 3 | 20 | 14 | 10 | 7 | 11 |
| Hepatitis E | 28 | 25 | 22 | 24 | 29 | 21 |
| Influenza virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Influenza A | 247 | 317 | 373 | 558 | 1,197 | 2,022 |
| Influenza B | 79 | 68 | 57 | 50 | 84 | 100 |
| Influenza indeterminate | - | 1 | - | 1 | 1 | 2 |
| Influenza ungrouped | 4 | 10 | 14 | 29 | 40 | 89 |
| Legionella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Legionella pneumophila | 4 | 6 | 2 | 6 | 4 | 4 |
| Legionella sp | 5 | 4 | 2 | 4 | 1 | 2 |
| Leptospira | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Leptospira interrogans | - | - | 1 | - | 1 | - |
| Listeria | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Listeria monocytogenes | 5 | 4 | 6 | 8 | 6 | 25 |
| Mycobacterium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mycobacterium tuberculosis | 72 | 90 | 71 | 75 | 63 | 67 |
| Neisseria | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Neisseria meningitidis | 26 | 32 | 31 | 35 | 26 | 36 |
| Orthopoxvirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Mpox virus | 8 | 10 | 7 | 5 | 2 | 3 |
| Paramyxoviruses | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Measles virus | 6 | 10 | 11 | 10 | 4 | 16 |
| Mumps virus | 4 | 7 | 3 | 6 | 1 | 5 |
| Plasmodium | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Plasmodium falciparum | - | 16 | - | 14 | - | 1 |
| Plasmodium ovale | - | 3 | - | 5 | - | - |
| Plasmodium vivax | - | 3 | - | - | - | - |
| Polyomavirus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Polyomavirus BK | 55 | 74 | 56 | 49 | 48 | 51 |
| Polyomavirus JC | 5 | 11 | 11 | 8 | 13 | 10 |
| Polyomavirus untyped | 12 | 15 | 18 | 7 | 21 | 14 |
| Rickettsia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rickettsia tsutsugamushi | - | - | - | 1 | 1 | - |
| Rubella virus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Rubella virus | 1 | 4 | 5 | 6 | 2 | 6 |
| Salmonella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Other salmonellas | 55 | 70 | 56 | 54 | 43 | 18 |
| Salmonella chester | - | - | 5 | - | - | - |
| Salmonella enteritidis | 75 | 58 | 43 | 29 | 29 | 10 |
| Salmonella infantis | 6 | - | - | - | - | - |
| Salmonella kentucky | - | - | - | 6 | - | - |
| Salmonella newport | 7 | 5 | 5 | - | - | - |
| Salmonella saint-paul | 9 | 10 | - | - | - | - |
| Salmonella sp | 13 | 16 | 18 | 17 | 58 | 89 |
| Salmonella stanley | - | 5 | - | 5 | - | - |
| Salmonella typhi and paratyphi | 16 | 12 | 26 | 30 | 17 | 9 |
| Salmonella typhimurium | 30 | 38 | 22 | 30 | 15 | 10 |
| Shigella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Shigella boydii | 2 | 2 | 4 | 1 | 1 | 1 |
| Shigella dysenteriae | - | - | 1 | 1 | 3 | - |
| Shigella flexneri | 17 | 23 | 17 | 16 | 18 | 9 |
| Shigella sonnei | 21 | 33 | 28 | 26 | 28 | 20 |
| Shigella sp | 58 | 60 | 48 | 59 | 56 | 52 |
| Streptococcus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Streptococcus group A | 46 | 59 | 61 | 65 | 59 | 64 |
| Streptococcus pneumoniae | 124 | 127 | 121 | 134 | 147 | 179 |
| Vibrio | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Vibrio cholerae | - | 2 | 1 | - | - | - |
Carbapenemase-producing Enterobacterales (CPE)
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/45 | 2023/46 | 2023/47 | 2023/48 | 2023/49 | 2023/50 | |
|---|---|---|---|---|---|---|---|
| Citrobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Citrobacter spp | IMP | 1 | - | - | - | - | - |
| Ìý | KPC | 2 | - | 1 | - | - | 2 |
| Ìý | NDM | 3 | - | - | - | 2 | - |
| Ìý | OXA48 | 3 | 2 | 3 | 2 | 1 | 2 |
| Ìý | VIM | 2 | - | - | - | - | - |
| Cronobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Cronobacter sakazakii | KPC | - | 1 | - | - | - | - |
| Other cronobacter spp | KPC | 1 | 1 | 1 | - | - | - |
| Enterobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Enterobacter cloacae complex | IMP | 3 | 2 | 1 | 2 | 2 | - |
| Ìý | KPC | 10 | 5 | 1 | 4 | 3 | 3 |
| Ìý | NDM | 5 | 4 | 9 | 4 | 5 | 1 |
| Ìý | OXA48 | 3 | 5 | 6 | 10 | 4 | 1 |
| Ìý | VIM | - | - | - | - | 1 | - |
| Ìý | Other | 1 | - | - | - | 2 | - |
| Other enterobacter spp | IMP | - | 1 | - | 2 | 1 | - |
| Ìý | NDM | 3 | - | 1 | 1 | 2 | - |
| Ìý | OXA48 | - | 1 | 1 | - | 1 | 1 |
| Escherichia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Escherichia coli | IMP | 1 | 1 | 1 | - | - | - |
| Ìý | KPC | 4 | 2 | 4 | 7 | 5 | 6 |
| Ìý | NDM | 15 | 11 | 16 | 18 | 18 | 5 |
| Ìý | OXA48 | 18 | 19 | 22 | 20 | 17 | 11 |
| Ìý | VIM | 1 | - | - | 1 | - | - |
| Ìý | Other | - | 2 | 1 | - | - | - |
| Escherichia vulneris | KPC | - | - | - | 1 | - | - |
| Other escherichia spp | IMP | - | - | - | 1 | - | - |
| Ìý | OXA48 | 1 | - | - | - | - | - |
| Hafnia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Hafnia alvei | OXA48 | - | 1 | - | - | - | - |
| Klebsiella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Klebsiella aerogenes | IMP | - | - | 1 | - | - | - |
| Ìý | KPC | 1 | - | - | - | - | - |
| Ìý | Other | - | - | - | - | 1 | - |
| Klebsiella oxytoca | IMP | 1 | - | - | - | - | - |
| Ìý | KPC | 5 | 3 | 2 | 5 | 2 | 2 |
| Ìý | NDM | - | - | - | - | 1 | - |
| Ìý | OXA48 | 1 | 2 | 5 | 1 | - | 1 |
| Klebsiella pneumoniae | IMP | - | - | 1 | - | 2 | - |
| Ìý | KPC | 14 | 9 | 16 | 6 | 8 | 3 |
| Ìý | NDM | 8 | 10 | 11 | 3 | 3 | 2 |
| Ìý | OXA48 | 8 | 9 | 13 | 16 | 12 | 1 |
| Ìý | VIM | - | 1 | 1 | 3 | - | - |
| Ìý | Other | 1 | 1 | 1 | 3 | - | 1 |
| Klebsiella serogenes | KPC | - | - | - | - | - | 1 |
| Klebsiella variicola | KPC | - | - | - | - | - | 1 |
| Ìý | OXA48 | - | - | - | - | - | 1 |
| Other klebsiella spp | NDM | - | - | - | 1 | - | - |
| Ìý | OXA48 | 1 | - | - | - | - | - |
| Leclercia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Leclercia adecarboxylata | KPC | - | - | - | - | 1 | - |
| Morganella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Morganella morganii | OXA48 | - | - | - | 1 | - | - |
| Pluralibacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Pluralibacter gergoviae | KPC | - | 1 | - | - | - | - |
| Proteus | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Proteus mirabilis | NDM | - | - | 1 | - | 1 | - |
| Ìý | OXA48 | - | 1 | - | - | - | - |
| Raoultella | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Raoultella ornithinolytica | OXA48 | - | 1 | - | - | - | - |
| Other raoultella spp | KPC | - | 1 | - | - | - | - |
| Other raoultella spp | OXA48 | - | 1 | - | - | - | - |
| Serratia | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Serratia marcescens/ureilytica | NDM | - | - | - | - | 1 | - |
Other carbapenemase-producing Gram-negative organisms
For all Carbapenemase-producing Gram-negative organisms, the reports are de-duplicated by first mention of organism species and resistance mechanism by person in a rolling 52-week period.
Note: the numbers presented here do not include specimens that have been referred to the AMRHAI Reference Unit.
| Week notification received | 2023/45 | 2023/46 | 2023/47 | 2023/48 | 2023/49 | 2023/50 | |
|---|---|---|---|---|---|---|---|
| Acinetobacter | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Acinetobacter baumannii | IMP | 1 | - | - | - | - | - |
| Ìý | NDM | 1 | - | - | 1 | - | 1 |
| Ìý | Other | - | - | 1 | - | - | - |
| Other acinetobacter spp | NDM | - | - | 1 | - | - | - |
| Pseudomonas | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Pseudomonas aeruginosa | IMP | - | 1 | - | - | - | - |
| Ìý | NDM | - | 1 | 3 | 1 | 1 | - |
| Ìý | VIM | 3 | - | - | - | 1 | - |
| Ìý | Other | 2 | 1 | - | 1 | 1 | 1 |
| Pseudomonas nitroreducens | NDM | - | - | - | - | 1 | - |
| Pseudomonas putida group | NDM | 1 | - | - | - | - | - |
| Ìý | VIM | 1 | - | - | - | - | - |
| Ìý | Other | - | 1 | - | - | - | - |
| Other pseudomonas spp | VIM | 1 | - | - | - | - | - |
| Other | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý | Ìý |
| Ìý | Other | - | 1 | - | - | - | - |